endstream endobj 137 0 obj <>stream 1,2 It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. References • “Induction of diabetes by Streptozotocin in rats” Use reagent-grade materials obtainable from various commercial vendors such as Sigma-Aldrich. Bioz Stars score: 99/100, based on 2105 PubMed citations. Working off-campus? METHODS: We implemented a comprehensive therapeutic strategy that included the tether system, permanent indwelling catheter … Frost. Shuyuan Chen. Southwest National Primate Research Center, San Antonio, TX, USA. ��C�Y������n��C������uiah��z ����o>F��!����� Please check your email for instructions on resetting your password. Streptozotocin found in: Streptozocin, Streptozotocin, Streptozocin is used for treating metastatic cancer in the pancreatic islet cells. Characterization of a PRISTANE‐induced lupus‐associated model in the non‐human primate cynomolgus monkey. Use the link below to share a full-text version of this article with your friends and colleagues. � ��Z4��F e��(G�{(۠�J=�X;P2n-��U0�F: '��X�8�{�*���]�pk)Zk(*��_'�}=�N�$��#d�4*>� ΋$,����*N7(y8-�,��s>L�˳�L����Ni�a�Ia�Y%ᦄl���+���K�%�,F}Jq$^�(i���P�>�-[�!��:el�(yg���ds�v��5��a.���iW�M���%,*#�=�34|3i��+�U��i KtT�x����H����ٚ'(�#zGX���K�r�� m޷����H��6S��>o��jt�Z��"9��A�N�j�y���yd:}�[�-���zܤ2)� t��Um]����h���UGC;N˵k'vbT�ub����䙫����fΤ Supplier to university and government institutions, hospitals and industry. A stock solution may be made by dissolving the STZ in the solvent of choice. ��濕⑺^�͟��+�k��"�v��\� �lYt�`�ƖlY�p!�f$0%� DAILY SCHEDULE:-Recommended Dose: 500 mg/m2 BSA IV by rapid injection or short/prolonged infusion once a day for 5 consecutive days every 6 weeks. Call our customer API support number 1-(800)-881-8210. Non‐human primate (NHP) diabetic models using chemical ablation of β‐cells with STZ have been achieved by several research groups. Learn more. Streptozotocin, supplied by Millipore, used in various techniques. endstream endobj 136 0 obj <>stream ASD samples were obtained by two methods: physical mixture (PM) and kneading (KND), which are the most commonly used methods to prepare solid dispersions due to their fast and straightforward approach. We successfully induced frank diabetes by IV administering a single dose of pharmaceutical‐grade STZ safely and without adverse events in conscious tethered baboons. LGM Pharma is a Streptozotocin CAS# 18883-66-4 API supplier distributor based in the USA. �U���8���`�ɳD����'�y�n�"�����v��BA�>�GN�$� �¼��yه|��� �ݦ�-�'���H��������f�g�A�޸����,4Ŝ��)�\����م�����Y�0G%:mP>��D��/:٨$�T�rbS���Hg%�670?`sͮJj��y[�����r�H��5|�:�{�=bx�= me��C���v��N��ơ�{�{�}��j/��A��?�Y�!M}[.�p]���C����KV Search for more papers by this author. Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line. h�bbd``b`�$���@�s�`� ���� r �r�Dp��������@�� $�$�.�L9$4o �X�1@��+�p�f`bd��L�gj| ` Y�m Since it carries a substantial risk of toxicity and rarely cures the cancer, its use is generally limited to patients whose cancer cannot be removed by surgery. ���.�d+�ǰw�iG̲�6����W��m��E_x���������VO��\�g�����4Ri�B�BK4�!�LK$�ȑ�o;5�k�����0l���%JcC9�[sO��\B�H����_ �A=T�-R���~d��1z3/�I��1�������>I�5��5 L�"��f�Ɖ����GP$�M�p��ڹ^��xUt�o��m�` ��;� Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. Streptozotocin has anticancer properties and is used for several tumors such as leukemia, medullary thyroid carcinoma, and islet cell cancer of the pancreas. H�\S�j�0}�W�Q[֪m��(�J�]ZHɃ���*�d$9�c�-����mf4�3g����������ƛG�K�iQ� �X��iK��,kڑ�X�����m��4��"ɒ�'�[Ҷ�a��%f��0�(# �ͼX1 ��C(h`����X��1TҊ8o��~R���}j�Ӣf]�-u����YF�%^`w���漘��V�fv��� �F�U(%����|�pq���ȴ ��4�&j. H�lTMo�0��W�8Kۉ���VUP!���$�Ɛ��|����{��7U+�^f�3o�{3�AP\EA�YIG?�y�ݮ}���nB��& g�`K����,_K�'�a�R����jl��`8T��u����ֹ����ڹr��T"�`��u�0ǹ�Jͯߩ�����y�a���k�$X]�v�O�5~�s�馰e^^o�8�a�Uc� =&��b b�*QL����P�=����"摇� ׺�l��u�@߼��L���S���5Һ�w9�i٩�Up����_�)I��b�S����v��S?+�c��0s�/����L�׶=��Rе7���PZ�75s�n�|��mU�~2�j��ܙ�>RLj! Streptozotocin (Streptozocin, STZ, Zanosar) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more. Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy. H�t�O��0���>!Gj�w|�t�Hh� q0��B� 7�~�'مv�P�{~��k !TNuV��8pF��3,yQ��V�5(�)��/t��B �۰i�tc*��? Streptozotocin (Streptozocin, STZ, Zanosar) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. :E��9*�L#,�F�#���#l��G쵇(�'}RaV��r?��kTr�,�,����$�tYɶ�oZ��>_��ov��gȝ[�����&+��������P���o�^Eo��}B����I4��L�|�G4G� �q͉_��+wЬ�&�E8��Va����g��e��L�ò*������U��@~�����Ut�r�+z�:���9�qE&�G�cmY���^�|��>�s� ���~�U/��t�W�H^��%�#�����?d�_�O�S���֫��ق�4���h�v�beJ�#� ��7 h�TP���0��{��$p[��B���K��k+��������Ӵ���I��$Y7��l ��N���dG7�F�`o ���a�ԃ� ���ǀCC����7��3l�_���o6Ȗz؜�s$���H2�*0� Y�?�A&ً;��X�|5vG�4���TYu$�>{(.��*��"�֕��+�T�g =1�l˽K�dn �/��'�T�_� ��h� Streptozotocin (Streptozocin, STZ, NSC 85998, Antibiotic U9889, Zanosar), CAS 18883-66-4, AG-CN2-0046, high purity chemical. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Number of times cited according to CrossRef: Research methodology for in vivo measurements of resting energy expenditure, daily body temperature, metabolic heat and non-viral tissue-specific gene therapy in baboons. DNA degradation was most extensive in recA E coli after streptozotocin treatment (400 ul 10-3 M for 30 min at 37 deg C), while comparable in recBC, alkA tag, and wild-type cells. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, orcid.org/http://orcid.org/0000-0002-4034-3062, I have read and accept the Wiley Online Library Terms and Conditions of Use. Physical mixture (PM) Chemotherapeutic STZ could lead to serious adverse events including nephrotoxicity, hepatotoxicity, and mortality. 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