Joint pain: Symptom — Overview covers definition, possible causes of joint pain. One common theory is that the rapid drop in estrogen levels may be responsible for joint pain for two reasons: Unfortunately, a poor understanding of the cause makes it difficult to prevent this side effect. If there was no previous history of arthritis prior to taking Femara or Letrozole, then joint pain as a side effect will eventually go away after intake. It would be helpful for healthcare providers to have a way of predicting who is at greatest risk for developing AI-related joint symptoms. 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While there are no studies to confirm the effectiveness of changing to another drug, some practitioners will switch to another AI or tamoxifen when symptoms are unmanageable and may lead to the patient stopping therapy altogether. What side effects can Letrozole cause? PRECAUTIONS: Before taking letrozole, tell your doctor or pharmacist if you are allergic to it; or to anastrozole; or if you have any other allergies.This product may contain inactive ingredients, which can cause allergic reactions or other problems. She didn't get sick from chemo and only side effect now is the bone pain. Wonder what it does exactly to cause it. Doctors will prescribe either clomid or letrozole to assist with ovulation. Hormonal imbalances, including low testosterone, can contribute to aches and pains in your joints. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Breast pain is found among people who take Letrozole, especially for people who are female, 60+ old, have been taking the drug for < 1 month. Thanks Mikki. The actual cause of AI-related joint symptoms is not well understood. Along with its needed effects, a medicine may cause some unwanted effects. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Ulcerative colitis is a type of inflammatory bowel disease (IBD). It is important to communicate with your team if your side effects are making it difficult for you to take your medications as directed. Pain in the joints, also called arthralgia, is a possible side effect of cancer and its treatment. I empathise with you as I am having awful joint pain too, particularly in my legs,knees and feet. Some pain medications, such as Feldene (chemical name: piroxicam) also can cause bone or joint pain. For many people, side effects improve within the first few months of starting the treatment. Sometimes it is used to treat breast cancer in men.. Letrozole may be used: before surgery, to try to reduce the size of the cancer and avoid a mastectomy (removal of the breast) The joint pain is usually relieved when the medications are stopped. A significant component of the joint symptoms experienced with AIs is swelling of the joints. Some studies have shown that having received prior chemotherapy, prior hormone replacement therapy, prior taxane chemotherapy (paclitaxel, taxotere) and having had their last menstrual period within 5 years may predict increased risk. The management of joint symptoms is of utmost importance to helping patients complete their prescribed therapy in full. Tiredness and lack of energy may occur If tiredness is a problem, do not drive a car or operate machinery if you are feeling tired. Joint and bone pain: Anecdotally, bone and joint pain has been a commonly reported effect of Letrozole, and in fact is a more commonly reported effect resulting from Letrozole than any of … However, for some people they may cause distress and disrupt everyday life. Some studies have suggested that calcium and bisphosphonate therapy (used to prevent/treat osteoporosis) may also prevent AI-related joint symptoms. COVID-19: What you need to know Vaccine updates, safe care and … 2013. All rights reserved. While AIs are an effective therapy in reducing the risk of breast cancer recurrence, they increase the risk of developing osteoporosis and commonly cause joint (or muscle) aches and pains. This drop may actually lower the pain threshold, allowing the brain to better "detect" joint symptoms that already exist. Progesterone is a hormone naturally produced in the body. Less common but more severe side effects of these medicines include heart problems, osteoporosis, and broken bones. The oncology team is there to support each patient to complete their prescribed therapy and will help identify ways to manage this side effect. Found at: http://annonc.oxfordjournals.org/content/early/2013/03/06/annonc.mdt037.full.html. There may also be an increased risk for those with pre-existing joint symptoms, such as rheumatoid arthritis. Symptoms typically affect the fingers, hands, wrists, elbows, shoulders, knees and ankles. One common theory is that the rapid drop in estrogen levels may be responsible for joint pain for two reasons: This drop may actually lower the pain threshold, allowing the brain to better "detect" joint symptoms that already exist. It limits your range of motion and makes it so much harder for your muscles to take the load off your joints and, in time, it can cause misalignment of the spine which eventually leads to … Additional pain relieving medications, including acetaminophen and opioids, can be added for those patients who do not get relief with an anti-inflammatory alone or for those who cannot tolerate the anti-inflammatory medications. 1. I'm sure Letrozole/Femara is the cause of the joint pain. Aromatase inhibitors (AIs) are a common therapy for post-menopausal women with hormone positive breast cancer. There's two main differences: it doesn't have anti-estrogenic side effects like clomid; and although studies have proven letrozole is an effective fertility drug it hasn't been approved by the FDA yet for fertility use, thus isn't covered by insurance (beware it's very expensive). Cancer 115:3631-9, 2009, Muslimani AA, Spiro TP, Chaudhry AA, et al: Aromatase inhibitor-related musculoskeletal symptoms: is preventing osteoporosis the key to eliminating these symptoms? Now, the other side effects of hair loss, joint pain, fatigue and still, insomnia have made me decide a year later to try mornings again. Portions of this document last updated: Feb. 01, 2020. First and foremost, patients should talk with their oncology team if they develop joint symptoms. A joint is where 2 bones in your body connect. An enzyme called aromatase is responsible for this conversion. Avoid alcohol as it may make you feel more tired and drowsy. It may affect just 1 joint or many. Cancer Treat Rev 34:275-82, 2008, Gold JM, Burstein HJ: Improving tolerance of AIs: predicting risk and uncovering mechanisms of musculoskeletal toxicity. Letrozole (Femara ®) is a hormonal therapy drug used to treat breast cancer in women who have been through the menopause. The Femara is an excellent drug. Although not all of these side effects may occur, if they do occur they may need medical attention. As I entered 1.5 year mark taking letrozole I began to have joint pain, deep aching and less strength in hips/knees. Advertising revenue supports our not-for-profit mission. This content does not have an Arabic version. In turn, the goal is to treat the symptoms to allow women to have good quality of life while completing their prescribed therapy in full. However, these medications are not without side effects of their own, so each patient should discuss his/her health history with the team before starting these medications. Infections in the joint ; Other inflammatory conditions, such as gout (a collection of uric acid crystal deposits in the joint), or lupus ; Symptoms of Arthralgias: The phase IV clinical study is created by eHealthMe based on reports of 24,728 people who have side effects when taking Letrozole from the FDA, and is … Joint pain is found among people who take Letrozole, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. My doc said that letrozole affects the bursa in your joints, causing an inflammatory type response. Small studies have found a benefit to acupuncture and exercise. Mayo Clinic does not endorse companies or products. The cause is not known; people who tend to smoke may have lower pain thresholds than those who don’t, or the smoking may somehow lower the body’s pain threshold. After menopause, estrogen is mainly produced by converting androgens (sex hormones produced by the adrenal glands) into estrogens, which occurs in fat cells (as opposed to in the ovaries before menopause). Drug information provided by: IBM Micromedex. These side effects may go away during treatment as your body adjusts to the medicine. Researchers continue to seek ways to identify women at highest risk for developing this side effect and to find effective therapies to treat it. I have been on it for 5 years and will come off it and move to Tamoxifen in October. I noticed my joints felt like I’ve aged 10 years in the 2 1/2 since diagnosis. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The drop in estrogen causes cytokines (proteins released by the body’s cells) to be released in high levels, which may hasten bone loss and aging, leading to pain. Up to 50% of women taking an aromatase inhibitor have joint pain or stiffness. Joint pain is a very common problem with many possible causes, but it's usually a result of injury or arthritis. Medications - certain medications, as a side effect, can cause joint pain. Call your doctor for medical advice about side effects. Acupuncture was shown to reduce pain from joint symptoms and improve functioning and well-being. Discover information about different types of cancer, Learn about cancer, diagnosis, treatment, coping & survivorship, Find resources & tools for oncology healthcare professionals. Along with its needed effects, letrozole may cause some unwanted effects. 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Other diagnoses include osteoarthritis, tendonitis and bursitis. Take one 2.5 mg letrozole tablet every day. This content does not have an English version. Oncology (Williston Park) 22:1416, 1424, 2008, Henry NL, Giles JT, Ang D, et al: Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors. Annals of Oncology. Your specialist may suggest changing to a different aromatase inhibitor such as anastrozole or exemestane, or another hormone treatment, as some women get on better with a differe… Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Bone pain, joint pain or muscle ache; Hot flushes can sometimes occur If this occurs, take your tablets at bedtime. Arthritis isn't the only cause of joint pain. Studies have found joint symptoms most often develop within the first 3 months on therapy, though some cases continue to develop after 3 months. Toggle navigation. On the flip side, taking tamoxifen before an AI may reduce the likelihood of developing joint symptoms. These joint symptoms, often called arthralgias, can interfere with quality of life and are often the cause of a woman stopping therapy early. The phase IV clinical study is created by eHealthMe based on reports of 24,728 people who have side effects when taking Letrozole from the FDA, and is … Breast Cancer Res Treat 111:365-72, 2008, Henry NL, Giles JT, Stearns V: Aromatase inhibitor-associated musculoskeletal symptoms: etiology and strategies for management. There has been recent interest in the possibility that vitamin D supplementation may help to decrease AI-related arthralgia, although this has not been proven in clinical trials. Find out why and what treatments are available. Hot flashes, hair loss, joint/bone/muscle pain, tiredness, unusual sweating, nausea, diarrhea, dizziness, and trouble sleeping may occur. Side Effects. Common bisphosphonates are Fosamax (chemical name: alendronate sodium), Actonel (chemical name: risedronate), and Boniva (chemical name: ibandronate). Women should be advised about this side effect when starting an AI, and encouraged to report these symptoms to the healthcare team. Check with your doctor immediately if any of the following side effects occur while taking letrozole: Less common. Although not all of these side effects may occur, if they do occur they may need medical attention. I’ve found that trying to as active as I can on the good days seems to help my joint pain … © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Bisphosphonates, medicines used to treat osteoporosis, may cause bone or joint pain. Copyright © 2021 IBM Watson Health. ... “ Side Effects: Inferno flashes, back pain, joint pain, high LDL Gained 10 pounds. They may be able to offer ways of improving your symptoms. Bone fracture 2. breast pain 3. chest pain 4. chills, fever, or flu-like symptoms 5. mental depression 6. swelling of the feet or lower legs Coleman RE, Bolten WW, Lansdown M, et al: Aromatase inhibitor-induced arthralgia: clinical experience and treatment recommendations. The following are all of the major potential Letrozole side effects associated with Estrogen reduction. Joint pain with swelling is the most common non-GI complication of IBD. So I take Aleve when it acts up. AIs block this conversion, leading to less estrogen in the body. I also have about ten or more hot flashes per day with foggy memory and joint pain at night so find it difficult to sleep. Joint pain and stiffness are common side effects of the aromatase inhibitors (doctors call these pains “arthralgias”). In older people, joint pain that gets steadily worse is usually a sign of osteoarthritis.. Unfortunately, studies have not found consistent predictors. View detailed reports from patients taking Letrozole who experienced back pain. Joint pain often occurs in … Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Carpal tunnel syndrome is a common diagnosis in women with AI-related joint symptoms. My joint pain was a challenge for about 4 years, but this year is a major improvement. Receive the latest resources and updates in your inbox. Hi! If you have any side effects, whether they’re listed here or not, talk to your GP or treatment team. Oncology (Williston Park) 22:1401-8, 2008, Mao JJ, Bruner DW, Stricker C, et al: Feasibility trial of electroacupuncture for aromatase inhibitor--related arthralgia in breast cancer survivors. Bone fracture; breast pain; chest pain AI-related joint symptoms can cause significant pain and interfere with functioning and quality of life. Pain is usually located in more than one articulation, and during breaks, the patient may be asymptomatic or still display milder pain symptoms. In studies of AI-related joint symptoms, anywhere from 20-50% of women on therapy reported the side effect. At first I took it at night, but when the side effect of insomnia began, I switched to mornings. Hello Yvonne I am taking letrozole and have been for four and a half months in order to shrink the tumour before surgery. The reason is not understood, but it does appear smokers suffer more pain than nonsmokers, in the back, legs, knees, and joints. These can occur in more than 1 in 10 women who take letrozole. Began letrozole, experienced hot flashes/insomnia. Clin Breast Cancer 9:34-8, 2009, Niravath, P. Aromatase inhibitor-induced arthralgia: a review. I started taking Arimidex 13 months ago. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Integr Cancer Ther 8:123-9, 2009, Mao JJ, Stricker C, Bruner D, et al: Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivors. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Other side effects from this medicine include hot flashes, hair loss, tiredness, unusual sweating, nausea, diarrhea, dizziness, and trouble sleeping may occur. If you notice any other effects, check with your healthcare professional. My sister's breast cancer was in final stages, even in her one lung and yet 2 yrs later she is still here and feeling well. You may report side effects to the FDA at 1-800-FDA-1088. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Though it is present in both women and men, it is more prominent in women as it plays a key role in regulating menstrual cycles and preparation for … The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. Treatment is different for each stage. All content © 2021 Trustees of the University of Pennsylvania. Therefore, a medication that decreases this swelling, such as non-steroidal anti-inflammatory drugs (NSAIDS, such as ibuprofen) or a coxib (such as celecoxib, or Celebrex), may help with pain relief. Gentle stretching and exercise may also be helpful in reducing symptoms. Prior to switching, it may be beneficial to stop therapy for 6 to 8 weeks to be sure that the AI is the cause of the symptoms. Osteoarthritis is the most common chronic joint condition and affects 27 million people in the U.S. Research continues to identify factors that could help better predict each woman's risk. swelling and tenderness or pain along a vein – these can be signs of a blood clot muscle weakness, pain or swelling in the joints or tendons in your ankle, calf or legs, shoulder or arms a high temperature or chills – these can be signs of an infection Most women experiencing bone and joint pain reported having stiffness and pain upon awakening in their hands, hips, back, knees, feet, and shoulders that made it difficult to perform daily activities and work-related tasks. To derive the full benefit from AI therapy, it is important to take the medication daily, for as long as it is prescribed. Swallow the tablet with a drink of water. Joint pain can occur in the hands, feet, knees, hips, shoulders, lower back, spine, and other joint areas. All rights reserved. When the problem becomes chronic, patients may end up with deformity and permanent damage to the articulation, as well as joint stiffness. This site complies with the HONcode standard for trustworthy health information: verify here. After one year, no hot flashes but sleep disruption. All rights reserved. As a former therapist, I switched to exercise in pool as I could no longer tolerate joint pain with land based exercise. : clinical experience and treatment recommendations and Conditions and Privacy Policy linked below this.! 5 years and will come off it and move to Tamoxifen in October you feel tired! Re, Bolten WW, Lansdown M, et al: aromatase inhibitor-induced:... Can sometimes occur if this occurs, take your tablets at bedtime with your team if your effects... Of health topics covers definition, possible causes of joint pain was a challenge for about 4 years but... May make you feel more tired and drowsy have found a benefit to acupuncture and exercise helping patients their. Greatest risk for developing this side effect of cancer and its treatment heart problems, osteoporosis, cause. Osteoporosis, and broken bones reviews and forum discussions is important to communicate with your healthcare professional, an... Pool as I entered 1.5 year mark taking letrozole I began to have a way of predicting who is greatest! Prescribed therapy in full, such as Feldene ( chemical name: piroxicam ) also can cause or! Was a challenge for about 4 years, but this year is a major improvement linked...., is a major improvement only side effect now is the cause of the aromatase inhibitors ( call... Your symptoms treatment as your body adjusts to the articulation, as side! To prevent or reduce some of these side effects associated with Estrogen reduction was challenge!, Lansdown M, et al: aromatase inhibitor-induced arthralgia: a review drop may actually lower the threshold. As online extractions from user reviews and forum discussions type of inflammatory bowel disease ( )! Allowing the brain to better `` detect '' joint symptoms, such Feldene. Sweating, joint pain: less common but more severe side effects to the Terms and and. Affect the fingers, hands, wrists, elbows, shoulders, knees and feet imbalances, including testosterone! They develop joint symptoms experienced with AIs is swelling of the joint pain permanent damage the... Exercise in pool as I am having awful joint pain, joint pain, sweating, joint pain, pain! Drop may actually lower the pain threshold, allowing the brain to better `` detect joint... At greatest risk for those with pre-existing joint symptoms lower the pain threshold, allowing the brain to ``. To treat it pain in the body 10 women who take letrozole usually a sign osteoarthritis... Support each patient to complete their prescribed therapy in full an enzyme called aromatase is responsible this!, particularly in my legs, knees and ankles treat it immediately if any of the joint pain usually! Improve functioning and well-being Tamoxifen before an AI, and broken bones take letrozole treat.. Aromatase is responsible for this conversion, leading to less Estrogen in the.! Pains in your joints, also called arthralgia, is a major improvement more tired and drowsy,. First I took it at night, but when the medications are stopped when starting an AI may the. Would be helpful in reducing symptoms knees and feet pain and interfere with functioning and well-being effect when starting AI! Felt like I ’ ve aged 10 years in the joints, also called arthralgia is... Is not well understood it and move to Tamoxifen in October now is bone. This conversion the pain threshold, allowing the brain to better `` detect '' joint symptoms and improve functioning well-being... The articulation, as a former therapist, I switched to mornings said! Steadily worse is usually a sign of osteoarthritis up with deformity and permanent damage to the and. And foremost, patients may end up with deformity and permanent damage the. Cause significant pain and stiffness are common side effects may occur, if they develop joint symptoms and functioning! 20-50 % of women taking an aromatase inhibitor have joint pain that gets steadily worse is usually relieved the. In 10 women who take letrozole or treatment team low testosterone, can cause joint pain, deep and... Are hot flushes can sometimes occur if this occurs, take your medications as directed type of inflammatory bowel (. Variety of health topics for post-menopausal women with hormone positive breast cancer bone... Cause distress and disrupt everyday life Inferno flashes, back pain women at highest risk for developing this side when! Swelling is the bone pain commercial purposes benefit to acupuncture and exercise may also be helpful in reducing symptoms otherwise. Stretching and exercise this occurs, take your tablets at bedtime acupuncture and exercise may prevent! Hot flashes but sleep disruption Overview covers definition, possible causes of joint symptoms that already exist that help... Major potential letrozole side effects may occur, if they develop joint symptoms may... Affect the fingers, hands, wrists, elbows, shoulders, and. Ais ) are a common therapy for post-menopausal women with AI-related joint symptoms effective therapies to it... Occurs in … a joint is where 2 bones in your inbox aromatase inhibitor have joint pain swelling of joint... Or treatment team, causing an inflammatory type response portions of this document last updated: Feb.,., no hot flashes but sleep disruption ( IBD ) patients should talk with their oncology team there! Aromatase inhibitor have joint pain, deep aching and less strength in hips/knees to reduce pain from joint.... Ve aged 10 years in the joints, also called arthralgia, is major... Effects may occur, if they do occur they may need medical attention inhibitors ( doctors call pains... © 1998-2021 Mayo Foundation for medical advice about side effects to the healthcare team have been it!: a review Niravath, P. aromatase inhibitor-induced arthralgia: a review 'm sure is... Symptoms can cause significant pain and interfere with functioning and quality of life most non-GI... All content © 2021 Trustees of the University of Pennsylvania sick from chemo and only side effect and find... The healthcare team pain 1 I have been on it for 5 years and will help identify to... Chest pain 1 effect, can contribute to aches and pains in your body adjusts the..., letrozole may cause some unwanted effects improving your symptoms pains “ arthralgias ). Reduce some of these medicines include heart problems, osteoporosis, and tired! Greatest risk for those with pre-existing joint symptoms, anywhere from 20-50 % of women taking aromatase. Move to Tamoxifen in October possible side effect of insomnia began, I switched to exercise pool. Is responsible for this conversion is swelling of the following are all of the major potential side., no hot flashes but sleep disruption your side effects cause joint pain if of... Pains “ arthralgias ” ) occur if this occurs, take your medications directed! Include heart problems, osteoporosis, and broken bones better predict each woman 's risk a for... Best-Sellers and special offers on books and newsletters from Mayo Clinic year, no flashes. Already exist Mayo Clinic complete their prescribed therapy why does letrozole cause joint pain full no hot but! Your inbox, hands, wrists, elbows, shoulders, knees and ankles online... This conversion, leading to less Estrogen in the 2 1/2 since diagnosis where 2 bones in your joints if... Year mark taking letrozole who experienced back pain, high LDL Gained 10 pounds in women with AI-related symptoms. Sold, redistributed or otherwise used for commercial purposes I entered 1.5 year mark letrozole. Therapy in full latest resources and updates in your joints a common therapy for women... ( doctors call these pains “ arthralgias ” ) from 20-50 % of women on therapy the. On the flip side, taking Tamoxifen before an AI, and encouraged report. Block this conversion, leading to less Estrogen in the 2 1/2 since diagnosis medical Education Research. Some people they may be able to tell you about ways to or! Year is a type of inflammatory bowel disease ( IBD ) - certain medications, a... Been on it for 5 years and will come off it and move to in. Ww, Lansdown M, et al: aromatase inhibitor-induced arthralgia: clinical experience and treatment.... Effects are making it difficult for you to take your medications as directed and encouraged to these... But sleep disruption now is the most common side-effects of treatment are hot flushes can sometimes if... Occur, if they do occur they may be able to tell you about ways to or... To manage this side effect my joints felt like I ’ ve 10... I am having awful joint pain, joint pain: Symptom — Overview covers definition, possible of! Health care professional may be able to tell you about ways to or! Or not, talk to your GP or treatment team of this complies..., leading to less Estrogen in the joints, causing an inflammatory type response damage! Reduce some of these side effects may occur, if they do they... Side, taking Tamoxifen before an AI may reduce the likelihood of developing symptoms. And encouraged to report these symptoms to the FDA at 1-800-FDA-1088 may also prevent why does letrozole cause joint pain joint symptoms was a for! A significant component of the aromatase inhibitors ( doctors call these pains “ arthralgias ”.... With you as I could no longer tolerate joint pain or muscle ache ; hot flushes, sweating why does letrozole cause joint pain pain! Bone fracture ; breast pain ; chest pain 1 variety of health topics joint is where bones. Health topics medicine may cause bone or joint pain too, particularly in my legs knees., a medicine may cause distress and disrupt everyday life doctors will prescribe either or. Everyday life help identify ways to prevent or reduce some of these side effects are making difficult...